TRIP12 - thyroid hormone receptor interactor 12 Gene

Also Known as ULF; MRD49; TRIPC; TRIP-12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9320

About TRIP12

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,763,837-229,923,186 (from NCBI)

This gene has 30 transcripts (splice variants), 215 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

TRIP12 Products (26)

mRNA	Protein	Name
NM_001284214.2	NP_001271143.1	E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001284215.2	NP_001271144.1	E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001284216.2	NP_001271145.1	E3 ubiquitin-protein ligase TRIP12 isoform d
NM_001348315.2	NP_001335244.1	E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001348316.2	NP_001335245.1	E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001348317.1	NP_001335246.1	E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348318.2	NP_001335247.1	E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348319.1	NP_001335248.1	E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348320.2	NP_001335249.1	E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348321.1	NP_001335250.1	E3 ubiquitin-protein ligase TRIP12 isoform g
NM_001348322.1	NP_001335251.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348323.3	NP_001335252.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348324.2	NP_001335253.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348325.2	NP_001335254.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348326.2	NP_001335255.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348327.2	NP_001335256.1	E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348328.1	NP_001335257.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348329.2	NP_001335258.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348330.2	NP_001335259.1	E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348331.1	NP_001335260.1	E3 ubiquitin-protein ligase TRIP12 isoform j
NM_001348332.1	NP_001335261.1	E3 ubiquitin-protein ligase TRIP12 isoform k
NM_001348333.1	NP_001335262.1	E3 ubiquitin-protein ligase TRIP12 isoform l
NM_001348334.1	NP_001335263.1	E3 ubiquitin-protein ligase TRIP12 isoform n
NM_001348335.2	NP_001335264.1	E3 ubiquitin-protein ligase TRIP12 isoform m
NM_001348336.1	NP_001335265.1	E3 ubiquitin-protein ligase TRIP12 isoform m
NM_004238.3	NP_004229.1	E3 ubiquitin-protein ligase TRIP12 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	7776974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18627766	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	18627766	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	19028681	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair-dependent chromatin remodeling	IMP IMP: Inferred from mutant phenotype	22884692	GOA
involved in heterochromatin boundary formation	IMP IMP: Inferred from mutant phenotype	22884692	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	30982744	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18627766	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19028681	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	20208519	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP12 Protein Structure

HECT

0
400
800
1200
1600
1992 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIP12	E3 ubiquitin-protein ligase for Arf

TRIP12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIP12	Q14669	MTNR1B	Homo sapiens	P49286	Y2H	26514267
Intra	TRIP12	Q14669	NPM1	Homo sapiens	P06748-1	Anti Tag CoIP	20208519
Intra	TRIP12	Q14669	MYC	Homo sapiens	P01106	Anti Bait CoIP	20208519
Intra	TRIP12	Q14669	MYC	Homo sapiens	P01106	Pull Down	20208519
Intra	TRIP12	Q14669	MYC	Homo sapiens	P01106	Anti Tag CoIP	20208519
Intra	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Pull Down	20208519
Intra	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	20208519
Intra	TRIP12	Q14669	CDKN2A	Homo sapiens	Q8N726	Anti Tag CoIP	20208519

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Clark-Baraitser Syndrome	CLABARS Baraitser Syndrome Autosomal Dominant Intellectual Disability 49 Mental Retardation, Autosomal Dominant 49, Formerly Mrd49, Formerly Intellectual Developmental Disorder, Autosomal Dominant 49 Autosomal Dominant Mental Retardation 49 Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features Mrd49 Progeria Short Stature Pigmented Nevi
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Developmental And Epileptic Encephalopathy 17	DEE17 Epileptic Encephalopathy, Early Infantile, 17 Eiee17 Developmental And Epileptic Encephalopathy, 17 Early Infantile Epileptic Encephalopathy 17 Developmental And Epileptic Encephalopathy, Type 17
Thyroid Dyshormonogenesis 1	TDH1 Hypothyroidism, Congenital, Due To Dyshormonogenesis, 1 Genetic Defect In Thyroid Hormonogenesis 1 Thyroid Hormonogenesis, Genetic Defect In, 1 Iodine Accumulation, Transport, Or Trapping Defect Iodide Accumulation, Transport, Or Trapping Defect Chdh1 Congenital Hypothyroidism Due To Dyshormonogenesis Type 1 Iodine Accumulation, Transport Or Trapping Defect
Alternating Exotropia	Exotropia
Anal Squamous Cell Carcinoma	Epidermoid Anal Carcinoma Carcinoma Of Anal Margin
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15078	TRIP12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21965	Trip12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28482	Trip12 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIP12	VGNC	VGNC:99414
Rattus norvegicus	TRIP12	RGD	RGD:1306607
Mus musculus	TRIP12	MGD	MGI:1309481
Canis familiaris	TRIP12	VGNC	VGNC:47845
Bos taurus	TRIP12	VGNC	VGNC:36358
Felis catus	TRIP12	VGNC	VGNC:66560
Others	TRIP12	NCBI