GLP2R - glucagon like peptide 2 receptor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9340

About GLP2R

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,825,924-9,892,099 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 42 paralogues. Biased expression in gall bladder (RPKM 4.7), small intestine (RPKM 2.6) and 8 other tissues.

Summary

This gene encodes a G protein-coupled receptor that is closely related to the Glucagon Receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte Apoptosis. [provided by RefSeq, Dec 2014]

GLP2R Products (1)

mRNA Protein Name
NM_004246.3 NP_004237.1 glucagon-like peptide 2 receptor

GLP2R Protein Structure

HRM

HRM: Hormone receptor domain (95 - 151)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (176 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

glucagon-like peptide 2 receptor

  • GLP-2 receptor

Related Diseases

Diseases Alias
Short Bowel Syndrome

  • Short Gut Syndrome

  • Acquired Short Bowel Syndrome

  • Secondary Short Bowel Syndrome

  • Short Bowel Nos
Ileus

  • Ileus Of Intestine
Chondrodysplasia, Blomstrand Type

  • Chondrodysplasia Blomstrand Type

  • BOCD

  • Blomstrand Lethal Chondrodysplasia

  • Blomstrand Lethal Osteochondrodysplasia

  • Blomstrand'S Lethal Chondrodysplasia

  • Blc

  • Blomstrand Chondrodysplasia

  • Blomstrand Osteochondrodysplasia
Mucositis

  • Inflammatory Disease Of Mucous Membrane

  • Gastrointestinal Mucositis
Isolated Growth Hormone Deficiency, Type Ib

  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P2221B Glepaglutide acetate Agonist 99.48% Phase 3
HY-P3291 Dapiglutide Agonist 98.52% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2221 Glepaglutide Agonist 99.70% Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-P10842 d-GLP-2 E33A Agonist / Unkown
HY-RS05491 GLP2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21583 Glp2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28101 Glp2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GLP2R VGNC VGNC:62587
Canis familiaris GLP2R VGNC VGNC:41267
Bos taurus GLP2R VGNC VGNC:29411
Macaca mulatta GLP2R VGNC VGNC:73073
Mus musculus GLP2R MGD MGI:2136733
Rattus norvegicus GLP2R RGD RGD:620270
Others GLP2R NCBI