GLP2R - glucagon like peptide 2 receptor Gene

Homo sapiens

Gene ID: 9340 | Gene type: protein coding

About GLP2R

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,825,924-9,892,099 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 42 paralogues. Biased expression in gall bladder (RPKM 4.7), small intestine (RPKM 2.6) and 8 other tissues.

Summary

This gene encodes a G protein-coupled receptor that is closely related to the Glucagon Receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte Apoptosis. [provided by RefSeq, Dec 2014]

GLP2R Products(1)

mRNA	Protein	Name
NM_004246.3	NP_004237.1	glucagon-like peptide 2 receptor

GLP2R Protein Structure

HRM

7tm_2

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

glucagon-like peptide 2 receptor

GLP-2 receptor

Related Diseases

Diseases

Alias

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Ileus

Ileus Of Intestine

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Mucositis

Inflammatory Disease Of Mucous Membrane

Gastrointestinal Mucositis

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2221B	Glepaglutide acetate	Agonist	98.47%	Phase 3
HY-P2221	Glepaglutide	Agonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3291	Dapiglutide	Agonist	96.01%	Unkown
HY-RS05491	GLP2R Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GLP2R	VGNC	VGNC:62587
Canis familiaris	GLP2R	VGNC	VGNC:41267
Bos taurus	GLP2R	VGNC	VGNC:29411
Macaca mulatta	GLP2R	VGNC	VGNC:73073
Mus musculus	GLP2R	MGD	MGI:2136733
Rattus norvegicus	GLP2R	RGD	RGD:620270
Others	GLP2R	NCBI

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