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Cat. No.: HY-P12211

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GLP2 (rat) (11-33)

GLP2 (rat) (11-33) is a glucagon-like peptide-2 receptor (GLP-2 receptor) antagonist. GLP2 (rat) (11-33) has weak intrinsic agonistic activity on human GLP-2R; it can synergistically enhance the activity of agonistic allosteric regulators on human, cynomolgus monkey, dog and Syrian hamster GLP-2R, but reduces this activity on rat GLP-2R. GLP2 (rat) (11-33) can be used for GLP-2R related research.

For research use only. We do not sell to patients.

Formula: C₁₂₂H₁₉₆N₃₂O₃₈
Molecular Weight:2719.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GLP2 (rat) (11-33) Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

GLP2 (rat) (11-33) has weak intrinsic agonistic activity on human GLP-2R; it can synergistically enhance the activity of agonistic allosteric regulators on human, cynomolgus monkey, dog and Syrian hamster GLP-2R, but reduces such activity on rat GLP-2R^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

GLP2 (rat) (11-33) (25 nmol/kg; s.c.; daily; 21 days) has no measurable effect on lipid homeostasis or bone resorption in healthy male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2719.05
Formula C₁₂₂H₁₉₆N₃₂O₃₈
SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N
Sequence

Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
Sequence Shortening

NTILDNLATRDFINWLIQTKITD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Baldassano S, et al. Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats. Frontiers in endocrinology. 2019;10:492.

[2]. Yamazaki K, et al. A novel truncated glucagon-like peptide 2 (GLP-2) as a tool for analyzing GLP-2 receptor agonists. Biomedical research (Tokyo, Japan). 2013 Jun;34(3):129-36.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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