Acsl5 - acyl-CoA synthetase long-chain family member 5 Gene

Also Known as Acs5; Facl5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 94340

Summary

Enables arachidonate-CoA Ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in mitochondrion. Colocalizes with endoplasmic reticulum. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Acsl5 Products (1)

mRNA	Protein	Name
NM_053607.2	NP_446059.2	long-chain-fatty-acid--CoA ligase 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate-CoA ligase activity	IDA IDA: Inferred from direct assay	28209804	RGD
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	9722683	RGD
enables long-chain fatty acid-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	22633490	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16198472	RGD
involved in fatty acid transport	IGI IGI: Inferred from genetic interaction	14711823	RGD
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	28209804	RGD
involved in long-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	22633490	RGD
involved in long-chain fatty-acyl-CoA biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in phospholipid biosynthetic process	IGI IGI: Inferred from genetic interaction	14711823	RGD
involved in positive regulation of fatty acid beta-oxidation	IGI IGI: Inferred from genetic interaction	14711823	RGD
involved in positive regulation of long-chain fatty acid import across plasma membrane	IDA IDA: Inferred from direct assay	16263710	RGD
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	16263710	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	9722683	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	16198472	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16772660	RGD
involved in response to sucrose	IEP IEP: Inferred from expression pattern	9722683	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
long-chain-fatty-acid--CoA ligase 5	LACS 5 arachidonate--CoA ligase fatty acid Coenzyme A ligase, long chain 5 long-chain acyl-CoA synthetase 5 long-chain fatty acid coenzyme A ligase 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177705	ACSL5-IN-2	Inhibitor	99.51%	Unkown
HY-177704	ACSL5-IN-1	Inhibitor	99.88%	Unkown
HY-186096	LP-856866	Inhibitor	99.92%	Unkown
HY-186095	LP-911888	Inhibitor	99.83%	Unkown
HY-177850	ACSL5-IN-3		99.74%	Unkown
HY-186084	ACSL5-IN-4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acsl5	NCBI	NCBI:51703