NCR2 - natural cytotoxicity triggering receptor 2 Gene

Also Known as LY95; CD336; NKP44; NK-p44; dJ149M18.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9436

About NCR2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,335,608-41,350,889 (from NCBI)

This gene has 3 transcripts (splice variants), 74 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable signaling receptor activity. Predicted to be involved in cellular defense response and signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NCR2 Products (3)

mRNA Protein Name
NM_001199509.2 NP_001186438.1 natural cytotoxicity triggering receptor 2 isoform 2 precursor
NM_001199510.2 NP_001186439.1 natural cytotoxicity triggering receptor 2 isoform 3 precursor
NM_004828.4 NP_004819.2 natural cytotoxicity triggering receptor 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10049942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (20 - 123)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 2

  • NK cell activating receptor (NKp44)

NCR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCR2 O95944 KMT2E Homo sapiens Q8IZD2-8
LexA B52 Complement
23958951
Intra
NCR2 O95944 KMT2E Homo sapiens Q8IZD2-8
Anti Bait CoIP
23958951
Intra
NCR2 O95944 KMT2E Homo sapiens Q8IZD2-8
Far-WB
23958951
Intra
NCR2 O95944 TYROBP Homo sapiens O43914
Anti Bait CoIP
14707061
Intra
NCR2 O95944 TYROBP Homo sapiens O43914
Anti Bait CoIP
10049942
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR2 Proteins

Cat. No. Product Name Accession Purity
HY-P72502 NKp44/NCR2 Protein, Human (HEK293, His) O95944/NP_004819.2 (Q22-P190) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74685 NKp44/NCR2 Protein, Human (Biotinylated, HEK293, His) O95944 (Q22-P190) ≥ 95%, as determined by reducing SDS-PAGE.

NCR2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86988 NK-p44 Antibody (YA6681) WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Newcastle Disease

  • Newcastle'S Disease

  • Pseudo-Fowlpest
Nk Cell Deficiency
Dermatitis, Atopic, 5

  • ATOD5

  • Atopic Dermatitis 5

  • Dermatitis, Atopic, Susceptibility To, 5

  • Dermatitis, Atopic 5
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09099 NCR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25266 Ncr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCR2 RGD RGD:1311406
Felis catus NCR2 VGNC VGNC:102474
Macaca mulatta NCR2 VGNC VGNC:75066
Others NCR2 NCBI