PAGE4 - PAGE family member 4 Gene

Also Known as JM27; JM-27; CT16.7; GAGE-9; GAGEC1; PAGE-1; PAGE-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9506

About PAGE4

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,829,260-49,834,264 (from NCBI)

This gene has 4 transcripts (splice variants), 47 orthologues and 22 paralogues. Restricted expression toward placenta (RPKM 272.2).

Summary

This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate Cancer. It is also expressed in Other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular Cancer and uterine Cancer. The protein encoded by this gene shares sequence similarity with Other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

PAGE4 Products (2)

mRNA Protein Name
NM_001318877.1 NP_001305806.1 P antigen family member 4
NM_007003.4 NP_008934.1 P antigen family member 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
21357425 GOA
enables nucleic acid binding EXP
EXP: Inferred from Experiment
21357425 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24263171 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
24263171 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
24559171 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
30658679 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
25374899 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21357425 GOA
involved in negative regulation of reactive oxygen species biosynthetic process IDA
IDA: Inferred from direct assay
25374899 GOA
involved in response to starvation IDA
IDA: Inferred from direct assay
25374899 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12489849 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25374899 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24559171 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAGE4 Protein Structure

GAGE

GAGE: GAGE protein (1 - 102)

  • 0
  • 102 a.a.
Protein Preferred Names Protein Names

P antigen family member 4

  • P antigen family, member 4 (prostate associated)

PAGE4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAGE4 O60829 JUN Homo sapiens P05412
NMR
26242913
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Progesterone-Receptor Negative Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09976 PAGE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown