ENTPD2 - ectonucleoside triphosphate diphosphohydrolase 2 Gene

Also Known as CD39L1; NTPDase-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 954

About ENTPD2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,048,107-137,054,061 (from NCBI)

This gene has 4 transcripts (splice variants), 250 orthologues and 7 paralogues. Broad expression in duodenum (RPKM 4.7), prostate (RPKM 4.6) and 17 other tissues.

Summary

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

ENTPD2 Products (2)

mRNA	Protein	Name
NM_001246.4	NP_001237.1	ectonucleoside triphosphate diphosphohydrolase 2 isoform 2
NM_203468.3	NP_982293.1	ectonucleoside triphosphate diphosphohydrolase 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD2 Protein Structure

GDA1_CD39

0
100
200
300
400
495 a.a.

Protein Preferred Names	Protein Names
ectonucleoside triphosphate diphosphohydrolase 2	CD39 antigen-like 1

ENTPD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ENTPD2	Q9Y5L3	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ENTPD2	Q9Y5L3	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ENTPD2	Q9Y5L3	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENTPD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72730	CD39L1/ENTPD2 Protein, Human (HEK293, His)	Q9Y5L3 (T29-D460)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76903	CD39L1/ENTPD2 Protein, Human (sf9, His)	Q9Y5L3 (T29-D460)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Jejunoileitis
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1	Van Der Knaap Disease Leukoencephalopathy With Swelling And Cysts MLC1 Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Lvm Vl Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1 Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1 Megalencephalic Leukoencephalopathy With Subcortical Cysts
Palmoplantar Keratoderma And Congenital Alopecia 1	Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia PPKCA1 Keratoderma-Hypotrichosis-Leukonychia Totalis Syndrome Autosomal Dominant Palmoplantar Hyperkeratosis And Congenital Alopecia Palmoplantar Keratoderma And Congenital Alopecia, Stevanovic Type Ppk-Ca, Stevanovic Type Ppkca, Stevanovic Type Palmoplantar Keratoderma With Congenital Alopecia Ppkca Stevanovic Type Alopecia Congenita With Hyperkeratosis Of The Palms And Soles Alopecia Congenita Keratosis Palmoplantaris Keratoderma, Palmoplantar, With Congenital Alopecia, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04396	ENTPD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18863	Entpd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25355	Entpd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991917	Anti-ENTPD2 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENTPD2	RGD	RGD:69266
Bos taurus	ENTPD2	VGNC	VGNC:28509
Mus musculus	ENTPD2	MGD	MGI:1096863
Felis catus	ENTPD2	VGNC	VGNC:61879
Macaca mulatta	ENTPD2	VGNC	VGNC:72225
Canis familiaris	ENTPD2	VGNC	VGNC:40381
Others	ENTPD2	NCBI