RABGAP1L - RAB GTPase activating protein 1 like Gene

Also Known as HHL; TBC1D18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9910

About RABGAP1L

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:174,159,520-174,995,308 (from NCBI)

This gene has 23 transcripts (splice variants), 277 orthologues and 45 paralogues. Ubiquitous expression in heart (RPKM 7.5), brain (RPKM 5.9) and 25 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within regulation of protein localization. Located in Golgi apparatus; early endosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RABGAP1L Products (19)

mRNA Protein Name
NM_001035230.3 NP_001030307.1 rab GTPase-activating protein 1-like isoform B
NM_001243763.2 NP_001230692.1 rab GTPase-activating protein 1-like isoform B
NM_001243764.2 NP_001230693.1 rab GTPase-activating protein 1-like isoform D
NM_001243765.2 NP_001230694.1 rab GTPase-activating protein 1-like isoform C
NM_001330989.2 NP_001317918.1 rab GTPase-activating protein 1-like isoform E
NM_001366445.1 NP_001353374.1 rab GTPase-activating protein 1-like isoform F
NM_001366446.1 NP_001353375.1 rab GTPase-activating protein 1-like isoform G
NM_001366447.1 NP_001353376.1 rab GTPase-activating protein 1-like isoform H
NM_001366448.1 NP_001353377.1 rab GTPase-activating protein 1-like isoform I
NM_001366449.1 NP_001353378.1 rab GTPase-activating protein 1-like isoform J
NM_001366450.1 NP_001353379.1 rab GTPase-activating protein 1-like isoform K
NM_001366451.1 NP_001353380.1 rab GTPase-activating protein 1-like isoform L
NM_001366452.1 NP_001353381.1 rab GTPase-activating protein 1-like isoform M
NM_001366453.1 NP_001353382.1 rab GTPase-activating protein 1-like isoform N
NM_001366454.1 NP_001353383.1 rab GTPase-activating protein 1-like isoform O
NM_001366455.1 NP_001353384.1 rab GTPase-activating protein 1-like isoform P
NM_001366456.1 NP_001353385.1 rab GTPase-activating protein 1-like isoform Q
NM_001366457.1 NP_001353386.1 rab GTPase-activating protein 1-like isoform R
NM_014857.5 NP_055672.3 rab GTPase-activating protein 1-like isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
16923123 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
16923123 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of protein localization IDA
IDA: Inferred from direct assay
16923123 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16923123 GOA
located in early endosome IDA
IDA: Inferred from direct assay
16923123 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16923123 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RABGAP1L Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (135 - 245)

DUF3694

DUF3694: Kinesin protein (290 - 421)

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (542 - 744)

  • 0
  • 200
  • 400
  • 600
  • 815 a.a.
Protein Preferred Names Protein Names

rab GTPase-activating protein 1-like

  • TBC1 domain family, member 18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11585 RABGAP1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RABGAP1L RGD RGD:1304620
Mus musculus RABGAP1L MGD MGI:1352507
Macaca mulatta RABGAP1L VGNC VGNC:76528
Others RABGAP1L NCBI