HS3ST1 - heparan sulfate-glucosamine 3-sulfotransferase 1 Gene

Also Known as 3OST; 3OST1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9957

About HS3ST1

Cytogenetic location: 4p15.33 Genomic coordinates (GRCh38): 4:11,393,150-11,434,327 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 10 paralogues. Ubiquitous expression in urinary bladder (RPKM 2.8), gall bladder (RPKM 0.9) and 19 other tissues.

Summary

Heparan sulfate biosynthetic Enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

HS3ST1 Products (1)

mRNA Protein Name
NM_005114.4 NP_005105.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
IDA: Inferred from direct assay
8900198 GOA
Biological Process GO Annotation Evidence References Source
involved in glycosaminoglycan biosynthetic process IDA
IDA: Inferred from direct assay
8900198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HS3ST1 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (55 - 294)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

heparan sulfate glucosamine 3-O-sulfotransferase 1

  • 3-OST-1

Recombinant HS3ST1 Proteins

Cat. No. Product Name Accession Purity
HY-P76974 HS3ST1 Protein, Human (sf9, His) O14792 (R21-H307) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Arteriosclerosis

  • Arteriosclerotic Vascular Disease
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Acute Retinal Necrosis Syndrome

  • Acute Retinal Necrosis

  • Retinal Necrosis Syndrome, Acute
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70171 Heparan Sulfate 3-O-Sulfotransferase 1 / Unkown
HY-RS06377 HS3ST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20556 Hs3st1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27065 Hs3st1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HS3ST1 VGNC VGNC:73525
Rattus norvegicus HS3ST1 RGD RGD:71084
Mus musculus HS3ST1 MGD MGI:1201606
Bos taurus HS3ST1 VGNC VGNC:29958
Canis familiaris HS3ST1 VGNC VGNC:41791
Others HS3ST1 NCBI