Tiparp - TCDD-inducible poly(ADP-ribose) polymerase Gene

Also Known as PARP7; ARTD14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99929

About Tiparp

Chromosome 3: 65,435,831-65,462,939 forward strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 208 orthologues, 7 paralogues and is associated with 68 phenotypes. Ubiquitous expression in bladder adult (RPKM 8.4), genital fat pad adult (RPKM 4.9) and 28 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within several processes, including animal organ development; cellular hormone metabolic process; and face morphogenesis. Predicted to be located in nucleus. Is expressed in bladder; reproductive system; telencephalon; and tongue. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]

Tiparp Products (1)

mRNA Protein Name
NM_178892.5 NP_849223.2 protein mono-ADP-ribosyltransferase TIPARP

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
23275542 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within estrogen metabolic process IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within excretion IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within metabolic process IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tiparp Protein Structure

WWE

WWE: pfam02825 (346 - 401)

TCCD_inducible_PARP_like

TCCD_inducible_PARP_like: cd01439 (528 - 647)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase TIPARP

  • ADP-ribosyltransferase diphtheria toxin-like 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181027 TIPARP-IN-1 Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-RS14546 TIPARP Human Pre-designed siRNA Set A / Unkown
HY-RS14547 Tiparp Mouse Pre-designed siRNA Set A / Unkown
HY-RS14548 Tiparp Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tiparp NCBI NCBI:25976