2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Geptanolimab

Geptanolimab  (Synonyms: APL-501; CBT-501; GB-226)

Cat. No.: HY-P99639 Purity: 97.72%
COA

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Geptanolimab (CBT-501) is a humanized IgG4k monoclonal antibody against programmed death-1 (PD-1). Siplizumab inhibits the binding of PD-L1/L2 to PD-1 through a competitive action. Siplizumab can be used in research of cancer.

For research use only. We do not sell to patients.

Geptanolimab Chemical Structure

Geptanolimab Chemical Structure

CAS No. : 2348469-43-0

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1 mg USD 300 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Geptanolimab Related Antibodies

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Description

Geptanolimab (CBT-501) is a humanized IgG4k monoclonal antibody against programmed death-1 (PD-1). Siplizumab inhibits the binding of PD-L1/L2 to PD-1 through a competitive action. Siplizumab can be used in research of cancer[1].

In Vitro

Geptanolimab (CBT-501) has highly specific binding to PD-1 of human (KD=505 pM) and cynomolgus (KD=7.2 nM)[1].
Geptanolimab enhances human T-cell activation in the Mix Lymphocyte Reaction (MLR), increasing release of IL-2 and INF-γ[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Geptanolimab Related Antibodies
In Vivo

Geptanolimab (ip; once every two weeks, for 6 weeks; mice with MC38 syngeneic tumor models) has anti-tumor activity and tumor inhibition rate reached 83%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Geptanolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97.72%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Geptanolimab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geptanolimab2348469-43-0APL-501 CBT-501 GB-226APL501APL 501CBT501CBT 501CBT-501GB226GB 226GB-226PD-1/PD-L1PD-1/Programmed death-ligand 1monoclonal antibodyIgG4kcancerPD-L1/L2T-cellInhibitorinhibitorinhibit

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