1. Immunology/Inflammation
    Antibody-drug Conjugate/ADC Related
  2. Glucocorticoid Receptor
    ADC Cytotoxin
  3. Glucocorticoid receptor agonist-1 Ala-Ala-Mal

Glucocorticoid receptor agonist-1 Ala-Ala-Mal 

Cat. No.: HY-137882
Handling Instructions

Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticosteroid, and an agonist of glucocorticoid receptor. Glucocorticoid receptor agonist-1 Ala-Ala-Mal can be conjugated with Adalimumab (HY-P9908) to prepare an ADC.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist-1 Ala-Ala-Mal Chemical Structure

Glucocorticoid receptor agonist-1 Ala-Ala-Mal Chemical Structure

CAS No. : 2166376-51-6

Size Price Stock Quantity
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticosteroid, and an agonist of glucocorticoid receptor. Glucocorticoid receptor agonist-1 Ala-Ala-Mal can be conjugated with Adalimumab (HY-P9908) to prepare an ADC[1].

Molecular Weight

862.96

Formula

C48H54N4O11

CAS No.
SMILES

O=C([[email protected]]([[email protected]@]1([H])C[[email protected]@]2([H])[[email protected]@](CCC3=CC4=O)([H])[[email protected]]([[email protected]]3(C=C4)C)([H])[[email protected]]5O)(O[[email protected]@](C(C=C6)=CC=C6CC7=CC(NC([[email protected]](C)NC([[email protected]](C)NC(CCN(C8=O)C(C=C8)=O)=O)=O)=O)=CC=C7)([H])O1)[[email protected]]2(C5)C)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (127.47 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1588 mL 5.7940 mL 11.5880 mL
5 mM 0.2318 mL 1.1588 mL 2.3176 mL
10 mM 0.1159 mL 0.5794 mL 1.1588 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (3.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.75 mg/mL (3.19 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.19 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Glucocorticoid receptor agonist-1 Ala-Ala-Mal
Cat. No.:
HY-137882
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