GPX4-IN-13
GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM).
For research use only. We do not sell to patients.
- CAS No.: 2644044-43-7
- Formula: C23H15NO3
- Molecular Weight:353.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
10.55 μM
Compound: Compound 16
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability measured after 72 hrs by MTT assay
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[PMID: 38306267] |
Chemical Information
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CAS No. 2644044-43-7
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Molecular Weight 353.37
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Formula C23H15NO3
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SMILES
O=C(C1=CC=C(C=C1)C#N)/C=C/C(C=CC=C2)=C2OC3=C(C=CC=C3)C=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPX4-IN-13 Related Classifications
HY-163995 Related Classifications
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