2644044-43-7
2644044-43-7
Chemical Structure
GPX4-IN-13
- CAS No.: 2644044-43-7
- Formula:C23H15NO3
- Molecular Weight:353.37
InChIKey: UNQJNKUGIZRZER-BUHFOSPRSA-N
SMILES: O=C(C1=CC=C(C=C1)C#N)/C=C/C(C=CC=C2)=C2OC3=C(C=CC=C3)C=O
Biological Activity: GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM)[1].
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GPX4-IN-13 | GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM). | |||||||||||||||||||||
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