2. PI3K/Akt/mTOR
    Stem Cell/Wnt
  3. GSK-3
  4. GSK3β inhibitor II

GSK3β inhibitor II 

Cat. No.: HY-14679
Handling Instructions

GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

GSK3β inhibitor II Chemical Structure

GSK3β inhibitor II Chemical Structure

CAS No. : 478482-75-6

Size Price Stock Quantity
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 155 In-stock
Estimated Time of Arrival: December 31
25 mg USD 325 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

GSK-3β

 

In Vitro

GSK3β inhibitor II shows the hydrophobic interaction with the Ile62, Phe67, Val70, Ala83, and Leu188, ionic inter action with the Lys85, and hydrogen bond interaction with the Lys85 and Val135 residues[1].
GSK3β inhibitor II forms a hydrogen bond with Val135[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

395.22

Formula

C14H10IN3OS
CAS No.
SMILES

IC1=CC=CC(CSC(O2)=NN=C2C3=CC=NC=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (126.51 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5302 mL 12.6512 mL 25.3024 mL
5 mM 0.5060 mL 2.5302 mL 5.0605 mL
10 mM 0.2530 mL 1.2651 mL 2.5302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.26 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GSK3β inhibitor II478482-75-6GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Alzheimer’s diseaseADInhibitorinhibitorinhibit

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