HBV-IN-29
HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection.
For research use only. We do not sell to patients.
- CAS No.: 2413192-59-1
- Formula: C22H19ClO6
- Molecular Weight:414.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HBV-IN-29 (ex8; 24 h) inhibits HBeAg levels and cell viability with an IC50 value of 1.34 μM in HepDES19 cells. HepDES19 is the cell line that produces cccDNA[1].
HBV-IN-29 (5 days) decreases cccDNA levels in HepDES19 cells in a dose-dependent manner[1].
HBV-IN-29 (9 days; primary human hepatocyte (PHH)) has anti-HBV effect and inhibits HBeAg with an IC50 value of 0.12 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413192-59-1
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Molecular Weight 414.84
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Formula C22H19ClO6
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SMILES
O=C(O)COC1CC(COC2=CC=C(C3=CC(C4=CC=CC(Cl)=C4O3)=O)C=C2)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBV-IN-29 Related Classifications
HY-148780 Related Classifications
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