HBV-IN-45
HBV-IN-45 is a selective and orally active HBV capsid assembly modulator with an IC50 of 0.51 μM for HBcAg in HBC cells. HBV-IN-45 shows potent anti-HBV activities.
For research use only. We do not sell to patients.
- Formula: C16H16N2O2S
- Molecular Weight:300.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
84.29 μM
Compound: 26f
|
Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis
Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis
|
[PMID: 38636128] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice injected with replication-competent HBV 1.3 DNA plasmid[1]
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Dosage:100 mg/kg
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Administration:Oral administration; twice daily; for 14 days
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Result:HBV DNA copy numbers were rapidly and markedly reduced in plasma.
Chemical Information
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Molecular Weight 300.38
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Formula C16H16N2O2S
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SMILES
COC1=CC=C(C=C1)SC2=NC3=CC=CC=C3N2CCO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)