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United States

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製品番号: HY-163516

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HBV-IN-45

HBV-IN-45 is a selective and orally active HBV capsid assembly modulator with an IC₅₀ of 0.51 μM for HBcAg in HBC cells. HBV-IN-45 shows potent anti-HBV activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₆H₁₆N₂O₂S
分子量:300.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HBV-IN-45 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

HBV-IN-45 is a selective and orally active HBV capsid assembly modulator with an IC₅₀ of 0.51 μM for HBcAg in HBC cells. HBV-IN-45 shows potent anti-HBV activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	84.29 μM Compound: 26f	Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis	[PMID: 38636128]

体外実験

HBV-IN-45 (compound 26f) inhibits the growth of HepG2 cells with a CC5₅₀ values of 84.29 μM. HBV-IN-45 also inhibits HBV DNA in HepAD38 cell supernatant with an EC₅₀ of 2.24 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

HBV-IN-45 (compound 26f; 100 mg/kg; oral administration; twice daily; for 14 days) inhibits HBV DNA copy numbers in plasma, and the HBeAg and liver enzymes GPT (ALT) in mouse serum have no difference^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/c mice injected with replication-competent HBV 1.3 DNA plasmid^[1]
Dosage:

100 mg/kg
Administration:

Oral administration; twice daily; for 14 days
Result:

HBV DNA copy numbers were rapidly and markedly reduced in plasma.

化学情報

分子量 300.38
分子式 C₁₆H₁₆N₂O₂S
SMILES

COC1=CC=C(C=C1)SC2=NC3=CC=CC=C3N2CCO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kaixin Du, et al. Development of benzimidazole-based compounds as novel capsid assembly modulators for the treatment of HBV infection. Eur J Med Chem. 2024 Apr 16:271:116402. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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