Atromentin
Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective enoyl-ACP reductase FabK inhibitor with an IC50 of 0.24 μM. Atromentin exhibits selectivity over FabI. Atromentin can be used for antimicrobial research.
For research use only. We do not sell to patients.
- CAS No.: 519-67-5
- Formula: C18H12O6
- Molecular Weight:324.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
5.71 μM
Compound: 7
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 36126897] |
Chemical Information
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CAS No. 519-67-5
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Molecular Weight 324.29
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Formula C18H12O6
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SMILES
O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3
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Structure Classification
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Initial Source
fungus F010248
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zheng CJ, et al. Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae. J Antibiot (Tokyo). 2006 Dec;59(12):808-12. [Content Brief]
[2]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atromentin Related Classifications
HY-165368 Related Classifications
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