2. MAPK/ERK Pathway
  3. MAP4K
  4. HPK1-IN-8

HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1.

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HPK1-IN-8

HPK1-IN-8 화학구조

CAS No. : 1214561-09-7

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

HPK1-IN-8 Related Antibodies

Top Publications Citing Use of Products

View All MAP4K Isoform Specific Products:

View All Isoforms
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1.

분자량

412.44

화학식

C19H17FN6O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC=C(CC2=CC=CC=C2F)S1)CC3=C(C)N=C(NN=C4C)N4C3=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

DMSO : 10 mg/mL (24.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4246 mL 12.1230 mL 24.2460 mL
5 mM 0.4849 mL 2.4246 mL 4.8492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4246 mL 12.1230 mL 24.2460 mL 60.6149 mL
5 mM 0.4849 mL 2.4246 mL 4.8492 mL 12.1230 mL
10 mM 0.2425 mL 1.2123 mL 2.4246 mL 6.0615 mL
15 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0410 mL
20 mM 0.1212 mL 0.6061 mL 1.2123 mL 3.0307 mL
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HPK1-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-81214561-09-7MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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Inquiry Information

상품명:
HPK1-IN-8
Cat. No.:
HY-132926
수량:
MCE Japan Authorized Agent:

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