ICG-DBCO
Based on 1 Customer Validation
ICG-DBCO is a near-infrared fluorescent click chemistry reagent (Ex/Em = 789/813 nm), composed of Indocyanine green (ICG) (HY-D0711) and dibenzocyclooctyne (DBCO). ICG-DBCO enables copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling biomolecules such as antibodies, proteins and peptides, thereby facilitating deep tissue optical imaging.
For research use only. We do not sell to patients.
- Purity: 98.83%
- CAS No.: 3024705-52-7
- Formula: C63H64N4O5S
- Molecular Weight:989.27
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50 is not present here; correcting to apply proper tags per rules:\nICG-DBCO (320 µM; 12 h) covalently binds to HA-N3 via copper-free click chemistry at a 4:1 molar ratio (ICG-DBCO:HA-N3) for 12 h at room temperature, forming an intermediate that self-assembles into HA@ICG NPs with a redshifted fluorescence emission peak at 830 nm[1].
IC50G-DBCO (8:1 molar ratio; 12 h) successfully labels peptide-polymer conjugates PEG-K(N3)-MP9 and PEG-K(N3)-MP9-aPDL1 via click chemistry to generate fluorescently tagged constructs for in vivo biodistribution studies[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3024705-52-7
-
Appearance Solid
-
Molecular Weight 989.27
-
Formula C63H64N4O5S
-
Color Brown to breen
-
SMILES
CC1(C)C2=C(C=CC3=C2C=CC=C3)N(CCCCCC(NCCC(N4CC5=C(C#CC6=C4C=CC=C6)C=CC=C5)=O)=O)/C1=C/C=C/C=C/C=C/C7=[N+](CCCCS(=O)([O-])=O)C8=C(C9=C(C=CC=C9)C=C8)C7(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (50.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Zhang H, et al. Hyaluronic acid modified indocyanine green nanoparticles: a novel targeted strategy for NIR-II fluorescence lymphatic imaging. Frontiers in chemistry. 2024;12:1435627. [Content Brief]
[2]. Lu L, et al. Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer. Theranostics. 2022;12(7):3456-3473. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0108 mL | 5.0542 mL | 10.1085 mL | 25.2712 mL |
| 5 mM | 0.2022 mL | 1.0108 mL | 2.0217 mL | 5.0542 mL | |
| 10 mM | 0.1011 mL | 0.5054 mL | 1.0108 mL | 2.5271 mL | |
| 15 mM | 0.0674 mL | 0.3369 mL | 0.6739 mL | 1.6847 mL | |
| 20 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2636 mL | |
| 25 mM | 0.0404 mL | 0.2022 mL | 0.4043 mL | 1.0108 mL | |
| 30 mM | 0.0337 mL | 0.1685 mL | 0.3369 mL | 0.8424 mL | |
| 40 mM | 0.0253 mL | 0.1264 mL | 0.2527 mL | 0.6318 mL | |
| 50 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5054 mL |
ICG-DBCO Related Classifications
HY-W588722 Related Classifications
Powered by Bioz