3024705-52-7
Chemical Structure
ICG-DBCO
- CAS No.: 3024705-52-7
- Formula:C63H64N4O5S
- Molecular Weight:989.27
InChIKey: PUWAOQDUALNQDB-UHFFFAOYSA-N
SMILES: CC1(C)C2=C(C=CC3=C2C=CC=C3)N(CCCCCC(NCCC(N4CC5=C(C#CC6=C4C=CC=C6)C=CC=C5)=O)=O)/C1=C/C=C/C=C/C=C/C7=[N+](CCCCS(=O)([O-])=O)C8=C(C9=C(C=CC=C9)C=C8)C7(C)C
Biological Activity: ICG-DBCO is a near-infrared fluorescent click chemistry reagent (Ex/Em = 789/813 nm), composed of Indocyanine green (ICG) (HY-D0711) and dibenzocyclooctyne (DBCO). ICG-DBCO enables copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling biomolecules such as antibodies, proteins and peptides, thereby facilitating deep tissue optical imaging[1][2].
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ICG-DBCO | 98.83% | ICG-DBCO is a near-infrared fluorescent click chemistry reagent (Ex/Em = 789/813 nm), composed of Indocyanine green (ICG) (HY-D0711) and dibenzocyclooctyne (DBCO). ICG-DBCO enables copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling biomolecules such as antibodies, proteins and peptides, thereby facilitating deep tissue optical imaging. | ||||||||||||||||||||
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- [1]. Zhang H, et al. Hyaluronic acid modified indocyanine green nanoparticles: a novel targeted strategy for NIR-II fluorescence lymphatic imaging. Frontiers in chemistry. 2024;12:1435627. [Content Brief]
- [2]. Lu L, et al. Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer. Theranostics. 2022;12(7):3456-3473. [Content Brief]
Keywords
