WDR91 - WD repeat domain 91 Gene
Also Known as SORF1; SORF-1; HSPC049
Species: Homo sapiens
About WDR91
This gene has 21 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues.
Summary
Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
WDR91 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001362736.2 | NP_001349665.1 | WD repeat-containing protein 91 isoform 2 |
| NM_001362737.2 | NP_001349666.1 | WD repeat-containing protein 91 isoform 1 |
| NM_001362738.2 | NP_001349667.1 | WD repeat-containing protein 91 isoform 4 |
| NM_014149.4 | NP_054868.3 | WD repeat-containing protein 91 isoform 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables phosphatidylinositol 3-kinase inhibitor activity |
IMP
IMP: Inferred from mutant phenotype
|
26783301 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17500595 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in early endosome to late endosome transport |
IMP
IMP: Inferred from mutant phenotype
|
26783301 | GOA |
| involved in regulation of protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
27126989 | GOA |
| NOT involved in ubiquitin-dependent protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
28404643 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
26783301 | GOA |
| located in early endosome membrane |
IDA
IDA: Inferred from direct assay
|
26783301 | GOA |
| located in endosome membrane |
IDA
IDA: Inferred from direct assay
|
26783301 | GOA |
| located in late endosome membrane |
IDA
IDA: Inferred from direct assay
|
26783301 | GOA |
WDR91 Protein Structure
WD40: WD domain, G-beta repeat (404 - 436)
WD40: WD domain, G-beta repeat (564 - 590)
WD40: WD domain, G-beta repeat (595 - 632)
WD40: WD domain, G-beta repeat (706 - 739)
- 0
- 200
- 400
- 600
- 747 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
WD repeat-containing protein 91 |
|
WDR91 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
WDR91 | A4D1P6 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
WDR91 | A4D1P6 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
WDR91 | A4D1P6 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
WDR91 | A4D1P6 | WDR81 | Homo sapiens | Q562E7 | 26783301 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Laryngotracheitis |
|
|
| Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | WDR91 | VGNC | VGNC:79464 |
| Mus musculus | WDR91 | MGD | MGI:2141558 |
| Rattus norvegicus | WDR91 | RGD | RGD:1306697 |
| Canis familiaris | WDR91 | VGNC | VGNC:48398 |
| Bos taurus | WDR91 | VGNC | VGNC:36927 |
| Felis catus | WDR91 | VGNC | VGNC:67063 |
| Others | WDR91 | NCBI |