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Cat. No.: HY-N14722

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Lactonamycin

Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC₅₀s of 0.06-3.3 μg/mL).

For research use only. We do not sell to patients.

CAS No.: 182234-02-2
Formula: C₂₈H₂₇NO₁₂
Molecular Weight:569.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Lactonamycin Chemical Structure

CAS No.: 182234-02-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
EL4	IC₅₀	112 nM Compound: 34	Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 38092421]
L1210	IC₅₀	153 nM Compound: 34	Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38092421]

Chemical Information

CAS No. 182234-02-2
Molecular Weight 569.51
Formula C₂₈H₂₇NO₁₂
SMILES

CO[C@](OC1)(CC(O2)=O)[C@]2(C(C(C(C3=O)=CC4=C5)=C(O)C4=C6C(C(N(C6)C)=O)=C5O)=O)[C@@]13O[C@@H]7O[C@H]([C@H](CC7)O)C
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Philip J Parsons, et al. An Approach to the Core of Lactonamycin. Org Lett. 2017 May 19;19(10):2533-2535. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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