An Approach to the Core of Lactonamycin

  • Org Lett. 2017 May 19;19(10):2533-2535. doi: 10.1021/acs.orglett.7b00902.
Philip J Parsons  1 ,  Daniel R Jones  1 ,  Lee J Walsh  1 ,  Lewis A T Allen  1 ,  Ada Onwubiko  1 ,  Lewis Preece  2 ,  Johnathan Board  2 ,  Andrew J P White  1
Affiliations
  • 1. Department of Chemistry, Imperial College London , South Kensington, London SW7 2AZ, U.K.
  • 2. Department of Chemistry, University of Sussex , Falmer, Brighton BN1 9RH, U.K.
PMID: 28445072 DOI: 10.1021/acs.orglett.7b00902
Abstract

A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the Antibiotic lactonamycin and Anticancer agent lactonamycin Z.

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