2. Anti-infection
  3. Bacterial
  4. Lactonamycin

Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC50s of 0.06-3.3 μg/mL).

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Lactonamycin

Lactonamycin Chemical Structure

CAS No. : 182234-02-2

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Lactonamycin Related Antibodies

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Description

Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC50s of 0.06-3.3 μg/mL)[1].

Cellular Effect
Cell Line Type Value Description References
EL4 IC50
112 nM
Compound: 34
Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 38092421]
L1210 IC50
153 nM
Compound: 34
Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38092421]
Molecular Weight

569.51

Formula

C28H27NO12
CAS No.
SMILES

CO[C@](OC1)(CC(O2)=O)[C@]2(C(C(C(C3=O)=CC4=C5)=C(O)C4=C6C(C(N(C6)C)=O)=C5O)=O)[C@@]13O[C@@H]7O[C@H]([C@H](CC7)O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lactonamycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactonamycin182234-02-2BacterialInhibitorinhibitorinhibit

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