Lactonamycin
Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC50s of 0.06-3.3 μg/mL).
For research use only. We do not sell to patients.
- CAS No.: 182234-02-2
- Formula: C28H27NO12
- Molecular Weight:569.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EL4 | IC50 |
112 nM
Compound: 34
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Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 38092421] |
| L1210 | IC50 |
153 nM
Compound: 34
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Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38092421] |
Chemical Information
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CAS No. 182234-02-2
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Molecular Weight 569.51
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Formula C28H27NO12
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SMILES
CO[C@](OC1)(CC(O2)=O)[C@]2(C(C(C(C3=O)=CC4=C5)=C(O)C4=C6C(C(N(C6)C)=O)=C5O)=O)[C@@]13O[C@@H]7O[C@H]([C@H](CC7)O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lactonamycin Related Classifications
HY-N14722 Related Classifications
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