IGF-1R inhibitor-2

Name: IGF-1R inhibitor-2
Brand: MedChemExpress
SKU: HY-145110
Rating: 4.5 (0 reviews)

製品番号: HY-145110 純度: 98.36%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

IGF-1R inhibitor-2 構造式

CAS 番号 : 1116236-15-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 538	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 538	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$530	在庫あり	Estimated Time of Arrival: December 31
10 mg	$860	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1640	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

IGF-1R

分子量

461.49

分子式

C₂₄H₂₄FN₇O₂

CAS 番号

1116236-15-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(NC2=C3C=CNC3=NC(NC4=C(OC)C=C(CCN(C5)C)C5=C4)=N2)C=CC=C1F)N

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (108.34 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1669 mL	10.8345 mL	21.6689 mL
5 mM	0.4334 mL	2.1669 mL	4.3338 mL
10 mM	0.2167 mL	1.0834 mL	2.1669 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.36%

Select Batch:

データシート (275 KB) SDS (251 KB)

COA (254 KB) HNMR (285 KB) RP-HPLC (170 KB) LCMS (290 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Stanley Dawes Chamberlain, et al. IR receptor tyrosine kinase and ALK kinase for treating cancer. WO2009020990 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1669 mL	10.8345 mL	21.6689 mL	54.1724 mL
	5 mM	0.4334 mL	2.1669 mL	4.3338 mL	10.8345 mL
	10 mM	0.2167 mL	1.0834 mL	2.1669 mL	5.4172 mL
	15 mM	0.1445 mL	0.7223 mL	1.4446 mL	3.6115 mL
	20 mM	0.1083 mL	0.5417 mL	1.0834 mL	2.7086 mL
	25 mM	0.0867 mL	0.4334 mL	0.8668 mL	2.1669 mL
	30 mM	0.0722 mL	0.3611 mL	0.7223 mL	1.8057 mL
	40 mM	0.0542 mL	0.2709 mL	0.5417 mL	1.3543 mL
	50 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0834 mL
	60 mM	0.0361 mL	0.1806 mL	0.3611 mL	0.9029 mL
	80 mM	0.0271 mL	0.1354 mL	0.2709 mL	0.6772 mL
	100 mM	0.0217 mL	0.1083 mL	0.2167 mL	0.5417 mL