1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor
  3. AGL-2263

AGL-2263 

Cat. No.: HY-112720 Purity: 95.80%
Handling Instructions

AGL-2263 is an insulin receptor (IR) blocker.

For research use only. We do not sell to patients.

AGL-2263 Chemical Structure

AGL-2263 Chemical Structure

CAS No. : 638213-98-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
25 mg USD 490 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE AGL-2263

    AGL-2263 purchased from MCE. Usage Cited in: Reprod Biol. 2019 Sep;19(3):293-298.

    Granulosa cells pretreated with AG1024 (10 or 5 μM, inhibitor of IGF-1R autophosphorylation) for 1 h before insulin stimulation for 24 h. Levels of P-AKT, P-ERK 1/2, and β-actin detected in whole-cell lysates.
    • Biological Activity

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    Description

    AGL-2263 is an insulin receptor (IR) blocker.

    IC50 & Target

    Insulin receptor[1].

    In Vitro

    AGL-2263 is an insulin receptor (IR) blocker[1].

    Molecular Weight

    322.27

    Formula

    C₁₇H₁₀N₂O₅

    CAS No.

    638213-98-6

    SMILES

    O=C(C1=CC(O)=C(O)C=C1)/C(C#N)=C/C2=CC=C(OC3=O)C(N3)=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (387.87 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1030 mL 15.5149 mL 31.0299 mL
    5 mM 0.6206 mL 3.1030 mL 6.2060 mL
    10 mM 0.3103 mL 1.5515 mL 3.1030 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.45 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (6.45 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Cell Assay
    [1]

    Trophoblast cells are prepared from normal or GDM placentas. They are incubated in the presence of stimulants, insulin (100 nM) or both insulin and AGL-2263 (AGL, 5 μM) IR blocker, together for 24 hr[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Product name:
    AGL-2263
    Cat. No.:
    HY-112720
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