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Cixutumumab

(Synonyms: IMC-A12; NSC742460)
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Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer.

For research use only. We do not sell to patients.

  • Purity: 99.63%
  • CAS No.: 947687-12-9
  • Molecular Weight:150 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cixutumumab
  • Experimental Validation Results for Cixutumumab
  • Experimental Validation Results for Cixutumumab
  • Cixutumumab Chemical Structure
    Cixutumumab Chemical Structure
CAS No.: 947687-12-9
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Cixutumumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Immobilized IGF-I R Protein, Human can bind Cixutumumab. The EC50 for this effect is 2.853 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Cixutumumab (HY-P99189, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda1 (HY-P99992, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Cixutumumab Chemical Structure
    1/16
  • Cixutumumab
  • Immobilized IGF-I R Protein, Human can bind Cixutumumab. The EC50 for this effect is 2.853 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Cixutumumab (HY-P99189, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda1 (HY-P99992, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).