CDD-1115

CDD-1115 potently inhibits recombinant BMPR2 kinase activity with an IC₅₀ of 1.8 nM^[1].
CDD-1115 (5-50 μM; thermal scanning from 20 to 95 °C) binds potently to purified recombinant human BMPR2 kinase domain, increasing its melting temperature by 15.7 °C at a concentration of 50 μM^[2].
CDD-1115 (30 min) potently inhibits purified recombinant human BMPR2 kinase activity with a K_iapp of 6.2 nM^[2].
CDD-1115 is a highly selective inhibitor of human BMPR2, with an IC₅₀ of 1.8 nM and >139-fold selectivity over other tested TGFβ family kinases^[2].
CDD-1115 (1 μM) exhibits high selectivity for human BMPR2 over a panel of 403 kinases, with only BMPR2 showing significant binding at a concentration of 1 μM^[2].
CDD-1115 (2.0 μM; 0-60 min) is metabolically unstable in human and mouse liver microsomes, with half-lives of 7 min and 12 min, respectively^[2].
CDD-1115 (30 min pretreatment, followed by 6 h incubation with 5 ng/mL BMP2) inhibits BMP2-mediated luciferase reporter activity in HEK293T-BRE-Luc cells with an IC₅₀ of 24.1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.