INCB106385
INCB106385 is an orally active A2A/A2B adenosine receptor antagonist, with an IC50 value of 4.4 nM for cAMP inhibition at the A2A adenosine receptor and an IC50 value of 6.4 nM for cAMP inhibition at the A2B adenosine receptor. INCB106385 inhibits the pCREB signaling pathway in immune cells, blocks adenosine-mediated immunosuppression in the tumor microenvironment, and induces tumor regression. INCB106385 exhibits efficacy as a monotherapy or in combination with anti-PD-1 antibodies in colon cancer models. INCB106385 can be used for the research of colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 2408260-34-2
- Formula: C23H17N9O
- Molecular Weight:435.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
|
A2AR |
A2BR |
INCB106385 (compound 36) inhibits cAMP production in A2A-overexpressing HEK293 cells with an IC50 of 4.4 nM[1].
INCB106385 inhibits cAMP production in A2B-overexpressing HEK293 cells with an IC50 of 6.4 nM[1].
INCB106385 inhibits phospho-CREB levels in human whole blood CD4+ T cells with an IC50 of 4.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2408260-34-2
-
Molecular Weight 435.44
-
Formula C23H17N9O
-
SMILES
N#CC1=CC=CC(C2=C(C(C=C3)=NN(C)C3=O)N4C(C(N)=N2)=NC(CC5=NC=CC=C5)=N4)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz