ADGRB3 - adhesion G protein-coupled receptor B3 Gene

Also Known as BAI3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 577

About ADGRB3

Cytogenetic location: 6q12-q13 Genomic coordinates (GRCh38): 6:68,635,282-69,389,506 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 42 paralogues. Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues.

Summary

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the Secretin Receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

ADGRB3 Products (1)

mRNA Protein Name
NM_001704.3 NP_001695.2 adhesion G protein-coupled receptor B3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21262840 GOA
Biological Process GO Annotation Evidence References Source
involved in myoblast fusion IDA
IDA: Inferred from direct assay
24567399 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IPI
IPI: Inferred from physical interaction
21262840 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRB3 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (296 - 342)

TSP_1

TSP_1: Thrombospondin type 1 domain (350 - 397)

TSP_1

TSP_1: Thrombospondin type 1 domain (405 - 452)

TSP_1

TSP_1: Thrombospondin type 1 domain (460 - 507)

HRM

HRM: Hormone receptor domain (512 - 570)

(586 - 806)

GPS

GPS: GPCR proteolysis site, GPS, motif (816 - 862)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (877 - 1143)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1522 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor B3

  • brain-specific angiogenesis inhibitor 3

ADGRB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Cross
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
SPR
21262840
Cross
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
Pull Down
21262840
Cross
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
Anti Tag CoIP
21262840
Intra
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Validated Y2H
32296183
Intra
ADGRB3 O60242 GPATCH11 Homo sapiens Q8N954
Validated Y2H
25416956
Intra
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Validated Y2H
32296183
Intra
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADGRB3 Proteins

Cat. No. Product Name Accession Purity
HY-P7675 BAI3 Protein, Human (HEK293, His) O60242 (A25-T880) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Polymicrogyria, Bilateral Frontoparietal

  • Bilateral Frontoparietal Polymicrogyria

  • BFPP

  • Cerebellar Ataxia With Neuronal Migration Defect
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Carey-Fineman-Ziter Syndrome 1

  • Carey-Fineman-Ziter Syndrome

  • CFZS

  • Congenital Nonprogressive Myopathy With Moebius And Robin Sequences

  • Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence

  • Cfz Syndrome

  • Carey Fineman Ziter Syndrome

  • Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences

  • Myopathy-Moebius-Robin Syndrome

  • CFZS1

  • Moebius Sequence, Robin Complex, And Hypotonia

  • Congenital Non-Progressive Myopathy With Moebius And Robin Sequences
Usher Syndrome, Type Iic

  • Usher Syndrome Type 2c

  • USH2C

  • Usher Syndrome, Type 2c

  • Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

  • Usher Syndrome Type Iic

  • Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

  • Usher Syndrome 2c

  • Usher'S Syndrome Type 2c

  • Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Vibratory Urticaria

  • Vibratory Angioedema

  • Dermodistortive Urticaria

  • VBU

  • Ddu

  • Angioedema, Vibratory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00347 ADGRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21813 Adgrb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28329 Adgrb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADGRB3 VGNC VGNC:59318
Felis catus ADGRB3 VGNC VGNC:69077
Canis familiaris ADGRB3 VGNC VGNC:37635
Rattus norvegicus ADGRB3 RGD RGD:1309703
Macaca mulatta ADGRB3 VGNC VGNC:81006
Mus musculus ADGRB3 MGD MGI:2441837
Others ADGRB3 NCBI