Propylthiouracil-d5
Propylthiouracil-d5 is the deuterium labeled Propylthiouracil. Propylthiouracil (6-Propyl-2-thiouracil) is a thyroperoxidase and 5'-deiodinase inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 1189423-94-6
- Formula: C7H5D5N2OS
- Molecular Weight:175.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189423-94-6
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Unlabeled Cas 51-52-5
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Molecular Weight 175.26
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Formula C7H5D5N2OS
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SMILES
[2H]C([2H])([2H])C([2H])([2H])CC1=CC(NC(N1)=S)=O
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Synonyms
6-n-Propylthiouracil-d5; 6-Propyl-2-thiouracil-d5; PTU-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Nakamura, H., et al., Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab, 2007. 92(6): p. 2157-62. [Content Brief]
[3]. Taurog, A. and M.L. Dorris, A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology, 1989. 124(6): p. 3038-42. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Propylthiouracil-d5 Related Classifications
HY-B0346S Related Classifications
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