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Cat. No.: HY-124454

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JCC76

JCC76 is the derivative of Nimesulide (HY-B0363). JCC76 inhibits the proliferation of Her2 positive breast cancer cell SKBR-3 with IC₅₀ of 3.43 μM.

For research use only. We do not sell to patients.

CAS No.: 1021926-22-6
Formula: C₂₄H₃₂N₂O₄S
Molecular Weight:444.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

JCC76 Chemical Structure

CAS No.: 1021926-22-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JCC76 is the derivative of Nimesulide (HY-B0363). JCC76 inhibits the proliferation of Her2 positive breast cancer cell SKBR-3 with IC₅₀ of 3.43 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	20 μM Compound: JCC-76	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 29352646]
MDA-MB-231	IC₅₀	20 μM Compound: JCC-76	Growth inhibition of human MDA-MB-231 cells Growth inhibition of human MDA-MB-231 cells	[PMID: 29352646]
NCI-H292	IC₅₀	22.1 μM Compound: 40	Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy	[PMID: 23306053]
NCI-H292	IC₅₀	7.99 μM Compound: 40	Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay	[PMID: 23306053]
SK-BR-3	IC₅₀	1 μM Compound: JCC-76	Growth inhibition of human SKBR3 cells Growth inhibition of human SKBR3 cells	[PMID: 29352646]
SK-BR-3	IC₅₀	1.38 μM Compound: 3, JCC76	Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay	[PMID: 22435708]
SK-BR-3	IC₅₀	1.38 μM Compound: JCC76	Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay	[PMID: 22119125]
SK-BR-3	IC₅₀	3.17 μM Compound: 49, JCC76	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay	[PMID: 23767669]
SK-BR-3	IC₅₀	3.43 μM Compound: JCC76	Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human SKBR3 cells after 48 to 72 hrs by MTT assay	[PMID: 21807508]

Chemical Information

CAS No. 1021926-22-6
Molecular Weight 444.59
Formula C₂₄H₃₂N₂O₄S
SMILES

O=C(C1CCCCC1)NC2=CC=C(N(S(=O)(C)=O)C)C(OCC3=CC(C)=CC=C3C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhong B, et al., Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5324-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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