SLC8A1 - solute carrier family 8 member A1 Gene

Also Known as NCX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6546

About SLC8A1

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:40,097,270-40,512,435 (from NCBI)

This gene has 19 transcripts (splice variants), 287 orthologues and 7 paralogues. Broad expression in heart (RPKM 35.6), endometrium (RPKM 9.9) and 16 other tissues.

Summary

In cardiac myocytes, CA(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in CA(2+) concentration during contraction is primarily due to release of CA(2+) from intracellular stores. However, some CA(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, CA(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the CA(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the CA(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

SLC8A1 Products (23)

mRNA	Protein	Name
NM_001112800.4	NP_001106271.1	sodium/calcium exchanger 1 isoform B precursor
NM_001112801.3	NP_001106272.1	sodium/calcium exchanger 1 isoform C precursor
NM_001112802.2	NP_001106273.1	sodium/calcium exchanger 1 isoform D precursor
NM_001252624.2	NP_001239553.1	sodium/calcium exchanger 1 isoform E precursor
NM_001351483.2	NP_001338412.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351484.2	NP_001338413.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351485.2	NP_001338414.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351486.2	NP_001338415.1	sodium/calcium exchanger 1 isoform G precursor
NM_001351487.2	NP_001338416.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351488.2	NP_001338417.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351489.2	NP_001338418.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351490.2	NP_001338419.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351491.2	NP_001338420.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351492.2	NP_001338421.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351493.2	NP_001338422.1	sodium/calcium exchanger 1 isoform E precursor
NM_001351494.2	NP_001338423.1	sodium/calcium exchanger 1 isoform D precursor
NM_001372263.2	NP_001359192.1	sodium/calcium exchanger 1 isoform A precursor
NM_001394103.1	NP_001381032.1	sodium/calcium exchanger 1 isoform A precursor
NM_001394104.1	NP_001381033.1	sodium/calcium exchanger 1 isoform B precursor
NM_001394105.1	NP_001381034.1	sodium/calcium exchanger 1 isoform H precursor
NM_001394106.1	NP_001381035.1	sodium/calcium exchanger 1 isoform D precursor
NM_001394107.1	NP_001381036.1	sodium/calcium exchanger 1 isoform D precursor
NM_021097.5	NP_066920.1	sodium/calcium exchanger 1 isoform A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ankyrin binding	IPI IPI: Inferred from physical interaction	17178715	GOA
enables calcium:sodium antiporter activity	IDA IDA: Inferred from direct assay	1374913	GOA
enables calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	25589784	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	26421717	GOA
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	16292983	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16292983	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion export	IDA IDA: Inferred from direct assay	19481548	GOA
involved in calcium ion import	IDA IDA: Inferred from direct assay	1374913	GOA
involved in calcium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	25589784	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	19481548	GOA
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	1374913	GOA
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	25589784	GOA
involved in positive regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in response to muscle stretch	IMP IMP: Inferred from mutant phenotype	15105296	GOA
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	19481548	GOA
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	1374913	GOA
involved in sodium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	25589784	GOA
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	25589784	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	21321244	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	1374913	GOA
located in synapse	IDA IDA: Inferred from direct assay	21382638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC8A1 Protein Structure

Na_Ca_ex

Calx-beta

Na_Ca_ex

0
200
400
600
800
973 a.a.

Protein Preferred Names	Protein Names
sodium/calcium exchanger 1	Na(+)/Ca(2+)-exchange protein 1

SLC8A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC8A1	P32418	S100A5	Homo sapiens	P33763	FPS	31837246
Intra	SLC8A1	P32418	S100A1	Homo sapiens	P23297	FPS	31837246

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC8A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82586	NCX1 Antibody (YA2331)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Megacolon	Dilatation Of Colon
Penile Cancer	Penis Carcinoma Carcinoma Of Penis Penile Neoplasm Penile Carcinoma Penile Neoplasms Malignant Neoplasm Of Penis Ca Penis Malignant Neoplasm Of Body Of Penis Malignant Penile Tumor Penile Ca
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Ischemia	Acute Coronary Syndrome
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3	Catecholaminergic Polymorphic Ventricular Tachycardia 3 CPVT3 Cvpt3 Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13337	SLC8A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13340	SLC8B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20598	Slc8b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27106	Slc8b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC8A1	RGD	RGD:3717
Canis familiaris	SLC8A1	VGNC	VGNC:46480
Felis catus	SLC8A1	VGNC	VGNC:81221
Bos taurus	SLC8A1	VGNC	VGNC:34935
Mus musculus	SLC8A1	MGD	MGI:107956
Macaca mulatta	SLC8A1	VGNC	VGNC:77634
Others	SLC8A1	NCBI