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Cat. No.: HY-N21799

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Hexadecyl ferulate

Hexadecyl ferulate is a lipophilic C16 alkyl ferulate synthesized from ferulic acid and cetyl alcohol, possessing free radical-scavenging antioxidant activity. Hexadecyl ferulate inhibits the formation of lipid oxidation products in soybean oil during deep frying and exhibits antioxidant efficacy that increases with alkyl chain length. Hexadecyl ferulate can be used in antioxidant-related research.

For research use only. We do not sell to patients.

CAS No.: 64190-80-3
Formula: C₂₆H₄₂O₄
Molecular Weight:418.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hexadecyl ferulate Chemical Structure

CAS No.: 64190-80-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Hexadecyl ferulate (HF) (0.1-50 μg/mL; 15 min) exhibits scavenging activity in the DPPH• radical scavenging assay with an IC₅₀ of 0.083 nM, and displays potent scavenging activity in the ABTS radical cation decolorization assay with an IC₅₀ of 0.027 nM^[1].
Hexadecyl ferulate (HF) (200 mg/kg) inhibits the formation of lipid oxidation products in a soybean oil high-temperature frying model system, and its antioxidant effect is superior to that of short-chain alkyl ferulates^[2].
Hexadecyl ferulate (FA C16) belongs to the class of alkyl ferulates and exhibits weak antioxidant or weak pro-oxidant effects in fish oil-fortified emulsion systems^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 64190-80-3
Molecular Weight 418.62
Formula C₂₆H₄₂O₄
SMILES

O=C(OCCCCCCCCCCCCCCCC)C=CC1=CC=C(O)C(OC)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nadal J, et al. A Simple and High-yield Synthesis of Hexadecyl Ferulate and Its In Vitro Antioxidant Potential. Brazilian Archives of Biology and Technology, 2018, 61.

[2]. Chen J, et al. Synthesized alkyl ferulates with different chain lengths inhibited the formation of lipid oxidation products in soybean oil during deep frying. Food chemistry. 2023 Jun 01;410:135458.

[3]. Sorensen A D M, et al. Alkyl chain length impacts the antioxidative effect of lipophilized ferulic acid in fish oil enriched milk. Journal of Functional Foods, 2015, 18(Part B): 959-967.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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