5-MCA-NAT
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 190277-13-5
- 分子式: C14H17N3O3
- 分子量:275.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Melatonin MT3 receptor[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
100 nM
Compound: MCA-NAT
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Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells
Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells
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[PMID: 18372181] |
| HEK293 | IC50 |
4 μM
Compound: MCA-NAT
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Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
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[PMID: 18372181] |
化学情報
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CAS 番号 190277-13-5
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分子量 275.30
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分子式 C14H17N3O3
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SMILES
O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121(8):1775-81. [Content Brief]
[2]. Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13(5):385-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
5-MCA-NAT 関連分類
HY-101303 関連分類
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