Antitumor agent-174
Antitumor agent-174 (Compound 10) directly engages the N-terminal site of Hsp90 and promotes the degradation of β-catenin, thereby suppressing the Wnt/β-catenin signaling. Antitumor agent-174 effectively inhibits proliferation, induce S and G2/M phases arrest and block the clonogenic ability in CRC cells. Antitumor agent-174 down-regulates CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, and upregulaties P21 proteins. Antitumor agent-174 has significant anti-tumor efficacy against colorectal cancer (CRC) with excellent pharmacokinetics and low toxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H18Cl2N2
- 分子量:357.28
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CDK1/cyclinB1 |
HSP90 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8.31 μM
Compound: 10
|
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
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[PMID: 39018921] |
| RKO | IC50 |
7.97 μM
Compound: 10
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Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
|
[PMID: 39018921] |
化学情報
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分子量 357.28
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分子式 C20H18Cl2N2
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SMILES
CC12C3=C(C(C=C(Cl)C=C4)=C4N3)CCN1CCC5=C2C=CC(Cl)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-174 関連分類
HY-161826 関連分類
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