BA6b9
BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
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- CAS 番号: 609335-29-7
- 分子式: C14H19NO2
- 分子量:233.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 8.6 μM (WT SK4 Channel)[1]
体外実験
BA6b9 (10 μM) strongly inhibits calcium-activated SK4 channels by raising the EC50 for Ca2+ activation from 65 nM to 435 nM [1]. BA6b9 (10 μM) exhibits a reduced heart rate, an increased PR interval, prolongation of atrial and atrioventricular effective refractory period (ERP) , and inhibits carbachol-induced atrial fibrillation (AF) in the Langendorff isolated heart model from adult male Sprague-Dawley rats (200-250 g) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 609335-29-7
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分子量 233.31
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分子式 C14H19NO2
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SMILES
O=C1OC2=C(N1CCCCCCC)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BA6b9 関連分類
HY-163735 関連分類
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