BCL6-IN-9
BCL6-IN-9 (compound 1) is a potent B-cell lymphoma 6 protein (BCL6) inhibitor, with an IC50 of 3.9 nM. BCL6-IN-9 can be used for the research of cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2378852-76-5
- 分子式: C22H18ClF2N5O2
- 分子量:457.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
IC50 & Target
IC50: 3.9 nM (B-cell lymphoma 6 protein)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KARPAS-422 | GI50 |
0.19 μM
Compound: 1
|
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
|
[PMID: 35657291] |
| OCI-Ly1 | GI50 |
0.17 μM
Compound: 1
|
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
|
[PMID: 35657291] |
| OCI-Ly3 | GI50 |
3.4 μM
Compound: 1
|
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay
|
[PMID: 35657291] |
化学情報
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CAS 番号 2378852-76-5
-
分子量 457.86
-
分子式 C22H18ClF2N5O2
-
SMILES
N#CC1=C(NC2=CC3=C(N(C)C(C4=C3N[C@@H](C5CC5)C(F)(F)CO4)=O)C=C2)C=CN=C1Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)