BI 7446
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2767011-00-5
- 分子式: C20H22FN9O10P2S2
- 分子量:693.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BI 7446 (CDN13) (3 μM, 10 μM, 6 h) increases IRF3 and TBK1 phosphorylation in THP1 STING-wild type cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:wild type and STING-knock out THP1 cells
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Concentration:3 μM, 10 μM
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Incubation Time:6 h
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Result:Observed a dose dependent increase of IRF3 and TBK1 phosphorylation in THP1 wild type cells but not in THP1 STING knockout cells.
BI 7446 (0.25, 1, 4 μg for subcutaneous injection, once weekly) generates tumor regression and a long-term immunologic memory against autologous tumor re-challenge in EMT6 mouse breast cancer model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 BALB/c mouse tumor model [1]
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Dosage:4, 12, 36 μg
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Administration:Intravenous injection (i.v.)
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Result:Observed a high plasma clearance and a short elimination half-life.
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Animal Model:EMT6 mouse breast cancer model[1]
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Dosage:0.25, 1, 4 μg
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Administration:Subcutaneous injection (s.c.)
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Result:Observed dose-dependent tumor regression even at the lowest tested dose.
Impaired the growth of the EMT6 tumors.
化学情報
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CAS 番号 2767011-00-5
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分子量 693.52
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分子式 C20H22FN9O10P2S2
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SMILES
O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BI 7446 関連分類
HY-155100 関連分類
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