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製品番号: HY-101773

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c-Met-IN-2

c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC₅₀ of 0.6 nM, with antitumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1635406-73-3
分子式: C₂₄H₂₁FN₁₀O
分子量:484.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

c-Met-IN-2 構造式

CAS 番号: 1635406-73-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC₅₀ of 0.6 nM, with antitumor activity.

IC₅₀ & Target

IC50: 0.6 nM (c-Met)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1993	IC₅₀	0.6 nM Compound: 14-2; Enantiomer-2	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
NCI-H1993	IC₅₀	0.7 nM Compound: 14-1; Enantiomer-1	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
NCI-H1993	IC₅₀	1.1 nM Compound: 14	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	0.6 nM Compound: 14-2; Enantiomer-2	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	0.8 nM Compound: 14-1; Enantiomer-1	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	2 nM Compound: 14	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]

体外実験

c-Met-IN-2 (Compound 14) is a potent and selective c-Met inhibitor, with an IC₅₀ of 0.6 nM. c-Met-IN-2 also shows weak activity on other kinases, with IC₅₀s of 1075 nM (AxI), 731 nM (RON), 18364 nM (VEGFR2), 5396 nM (c-Kit), 2357 nM (PDGFRa), 17056 nM (c-Src).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumor in mice bearing H1993 tumors, and has similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

化学情報

CAS 番号 1635406-73-3
分子量 484.49
分子式 C₂₄H₂₁FN₁₀O
SMILES

OCCN1N=CC(C2=CN=C3C(N(C(C4=C(F)C=C(N=CC(C5=CN(C)N=C5)=C6)C6=C4)C)N=N3)=N2)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhao F, et al. Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural opt [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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