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製品番号: HY-160129

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Centanamycin

Name: Centanamycin
Brand: MedChemExpress
SKU: HY-160129
Availability: PreOrder

(別名: ML-970; AS-I-145; NSC 716970)

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening.

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CAS 番号: 413577-16-9
分子式: C₂₄H₂₄ClN₃O₄
分子量:453.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Centanamycin 構造式

CAS 番号: 413577-16-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	0.045 μM Compound: 11a	The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50% The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%	[PMID: 15916443]
L1210	IC₅₀	0.18 μM Compound: 11a	The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50% The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%	[PMID: 15916443]
L1210	IC₅₀	55 nM Compound: 6	Cytotoxicity against mouse L1210 cells after 3 days by MTT assay Cytotoxicity against mouse L1210 cells after 3 days by MTT assay	[PMID: 20579889]
P815	IC₅₀	0.068 μM Compound: 11a	The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50% The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%	[PMID: 15916443]
P815	IC₅₀	0.068 μM Compound: 4, CBI-TMI	Cytotoxicity against mouse P815 cells after 3 days Cytotoxicity against mouse P815 cells after 3 days	[PMID: 16919946]

化学情報

CAS 番号 413577-16-9
分子量 453.92
分子式 C₂₄H₂₄ClN₃O₄
SMILES

O=C(C1=CC2=C(N1)C(OC)=C(OC)C(OC)=C2)NC3=C(CCCl)C4=C(C=CC=C4)C(N)=C3
別名

ML-970; AS-I-145; NSC 716970
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Rayburn E, et al. Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent. Cancer Chemother Pharmacol. 2012;69(6):1423-1431. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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