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United States

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製品番号: HY-W457608

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CU7218

CU7218 competitively binds to the phosphopeptide-binding pocket of 14-3-3ε and blocks its interaction with the 9J10 peptide. CU7218 can be used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 34330-04-6
分子式: C₈H₆N₂O₃S₂
分子量:242.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CU7218 構造式

CAS 番号: 34330-04-6

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CU7218 competitively binds to the phosphopeptide-binding pocket of 14-3-3ε and blocks its interaction with the 9J10 peptide. CU7218 can be used in cancer research^[1].

体外実験

CU7218 (0-1 mM; 20 min) inhibits the interaction between the 9J10 phosphopeptide and 14-3-3ε protein in fluorescence polarization (FP) assays, with an IC₅₀ of 111 μM^[1].
CU7218 (0-1 mM; 20 min) inhibits the interaction between the 9J10 phosphopeptide and 14-3-3ε protein in MST assays, with an IC₅₀ of 26.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 34330-04-6
分子量 242.27
分子式 C₈H₆N₂O₃S₂
SMILES

O=C(C1=C(C)C2=C(NC(NC2=O)=S)S1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Emery A, et al. Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library. Cell Chem Biol. 2021;28(11):1602-1615.e9. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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