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製品番号: HY-14767

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Fasobegron

Fasobegron is a β₃-adrenergic receptor agonist with a human EC₅₀ of 4.8 nM. Fasobegron shows an EC₅₀ of 250 nM for human β₁-adrenergic receptors. Fasobegron can be used for the research of overactive bladder.

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CAS 番号: 643094-49-9
分子式: C₂₄H₂₄ClNO₄
分子量:425.91

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fasobegron 構造式

CAS 番号: 643094-49-9

容量

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

β3 adrenoceptor

4.8 nM (EC₅₀)

β1 adrenoceptor

250 nM (EC₅₀)

Adrenergic Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>1 μM Compound: 1a	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	>1 μM Compound: 9d	Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	250 nM Compound: 1a	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	251 nM Compound: 9d	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	4.8 nM Compound: 1a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	4.8 nM Compound: 8a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	4.8 nM Compound: 9d	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]

体外実験

Fasobegron (Compound 1a) potently and selectively activates human β₃-ARs in CHO cells, with an EC₅₀ of 4.8 nM, and exhibits >2000-fold selectivity over human β₂-ARs (EC50 >10000 nM) and ~52-fold selectivity over human β₁-ARs (EC50 = 250 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 643094-49-9
分子量 425.91
分子式 C₂₄H₂₄ClNO₄
SMILES

O(C)C=1C=C(C=CC1C(O)=O)C2=CC=C(CCNC[C@H](O)C3=CC(Cl)=CC=C3)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hattori K, et al. Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem. 2009;52(9):3063-3072. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Fasobegron

Adrenergic Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Fasobegron 関連分類

HY-14767 関連分類