ADAM8 - ADAM metallopeptidase domain 8 Gene
Also Known as MS2; CD156; CD156a
生物種: Homo sapiens
About ADAM8
This gene has 11 transcripts (splice variants), 245 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 22.3), spleen (RPKM 13.4) and 12 other tissues.
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including Asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
ADAM8 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| XR_007061938.1 | ||
| XM_047424425.1 | XP_047280381.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform X3 |
| XM_047424423.1 | XP_047280379.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform X1 |
| NM_001164489.2 | NP_001157961.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor |
| NM_001164490.2 | NP_001157962.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform 3 |
| NM_001109.5 | NP_001100.3 | disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor |
| XM_047424424.1 | XP_047280380.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform X2 |
| XM_047424426.1 | XP_047280382.1 | disintegrin and metalloproteinase domain-containing protein 8 isoform X4 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables immunoglobulin receptor binding |
IPI
IPI: Inferred from physical interaction
|
12777399 | GOA |
| enables metallopeptidase activity |
IDA
IDA: Inferred from direct assay
|
12777399 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15574124 | GOA |
| enables tumor necrosis factor receptor superfamily binding |
IPI
IPI: Inferred from physical interaction
|
12777399 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in cellular response to hypoxia |
IDA
IDA: Inferred from direct assay
|
18566576 | GOA |
| involved in inflammatory response |
IDA
IDA: Inferred from direct assay
|
12777399 | GOA |
| involved in positive regulation of membrane protein ectodomain proteolysis |
IDA
IDA: Inferred from direct assay
|
15220135 | GOA |
| involved in positive regulation of neutrophil extravasation |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| involved in regulation of cell-cell adhesion |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| involved in signal release |
IDA
IDA: Inferred from direct assay
|
12777399 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
18397961 | GOA |
| located in dense core granule membrane |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| located in phagolysosome |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| located in podosome |
IDA
IDA: Inferred from direct assay
|
15220135 | GOA |
| located in specific granule |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
| located in tertiary granule |
IDA
IDA: Inferred from direct assay
|
17548643 | GOA |
ADAM8 Protein Structure
Pep_M12B_propep: Reprolysin family propeptide (29 - 155)
Reprolysin: Reprolysin (M12B) family zinc metalloprotease (200 - 400)
Disintegrin: Disintegrin (417 - 491)
ADAM_CR: ADAM cysteine-rich (494 - 567)
- 0
- 200
- 400
- 600
- 824 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
disintegrin and metalloproteinase domain-containing protein 8 |
|
|
ADAM8 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
ADAM8 | P78325 | TEC | Homo sapiens | P42680 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | TEC | Homo sapiens | P42680 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | NCF1 | Homo sapiens | P14598 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | NCF1 | Homo sapiens | P14598 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | FNBP1L | Homo sapiens | Q5T0N5 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | FNBP1L | Homo sapiens | Q5T0N5 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | TRIP10 | Homo sapiens | Q15642 | 25825872 | |
|
Intra
|
ADAM8 | P78325 | TRIP10 | Homo sapiens | Q15642 | 25825872 |
Recombinant ADAM8 Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P75532 | ADAM8 Protein, Human (HEK293, His) | AAI15405.1 (I17-P655) | ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE. |
ADAM8 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P83502 | MS2 Antibody (YA3247) | WB, IP | Human, Mouse, Rat |
| HY-P83502A | MS2 Antibody (YA3247)(PBS only) | WB, IP | Human, Mouse |
| HY-P84436 | MS2 Antibody (YA4133) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84436A | MS2 Antibody (YA4133)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Asthma |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Macaca mulatta | ADAM8 | VGNC | VGNC:69494 |
| Mus musculus | ADAM8 | MGD | MGI:107825 |
| Canis familiaris | ADAM8 | VGNC | VGNC:37587 |
| Bos taurus | ADAM8 | VGNC | VGNC:25612 |
| Felis catus | ADAM8 | VGNC | VGNC:59584 |
| Rattus norvegicus | ADAM8 | RGD | RGD:1566394 |
| Others | ADAM8 | NCBI |
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