CALR3 - calreticulin 3 Gene

Also Known as CRT2; CT93; CMH19

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 125972

About CALR3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,479,061-16,496,167 (from NCBI)

This gene has 3 transcripts (splice variants), 117 orthologues, 3 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 33.9).

Summary

The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than Other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]

CALR3 Products (1)

mRNA Protein Name
NM_145046.5 NP_659483.2 calreticulin-3 precursor

CALR3 Protein Structure

Calreticulin

Calreticulin: Calreticulin family (21 - 318)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

calreticulin-3

  • calreticulin-2

Recombinant CALR3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7712 Calreticulin-3/CALR3 Protein, Human Q96L12 (T20-L384) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 14

  • Hypertrophic Cardiomyopathy 14

  • CMH14

  • Cardiomyopathy, Hypertrophic, 14

  • Cardiomyopathy Familial Hypertrophic 14

  • Cardiomyopathy, Familial Hypertrophic 14

  • Cardiomyopathy, Hypertrophic, Familial, Type 14
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Pulmonary Adenocarcinoma In Situ

  • Bronchioalveolar Carcinoma
Lung Carcinoma In Situ
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01848 CALR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20371 Calr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26881 Calr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris CALR3 VGNC VGNC:38675
Macaca mulatta CALR3 VGNC VGNC:108487
Rattus norvegicus CALR3 RGD RGD:1309243
Mus musculus CALR3 MGD MGI:1920566
Felis catus CALR3 VGNC VGNC:69364
Bos taurus CALR3 VGNC VGNC:26716
Others CALR3 NCBI