MYO3B - myosin IIIB Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 140469

About MYO3B

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:170,178,147-170,655,167 (from NCBI)

This gene has 9 transcripts (splice variants), 187 orthologues and 43 paralogues. Biased expression in kidney (RPKM 2.4), urinary bladder (RPKM 2.3) and 4 other tissues.

Summary

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

MYO3B Products (2)

mRNA Protein Name
NM_001083615.4 NP_001077084.2 myosin-IIIb isoform 1
NM_138995.5 NP_620482.3 myosin-IIIb isoform 2

MYO3B Protein Structure

Pkinase

Pkinase: Protein kinase domain (27 - 293)

Myosin_head

Myosin_head: Myosin head (motor domain) (346 - 1046)

IQ

IQ: IQ calmodulin-binding motif (1089 - 1108)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1341 a.a.
Protein Preferred Names Protein Names

myosin-IIIb

MYO3B Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MYO3B Q8WXR4 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Deafness, Autosomal Recessive 30

  • DFNB30

  • Autosomal Recessive Nonsyndromic Deafness 30

  • Autosomal Recessive Deafness 30

  • Deafness, Autosomal Recessive, 30

  • Deafness, Autosomal Recessive, Type 30
Entropion
Autosomal Recessive Nonsyndromic Deafness

  • Deafness, Autosomal Recessive, Nonsyndromic
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08945 MYO3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22664 Myo3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29178 Myo3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta MYO3B VGNC VGNC:74961
Mus musculus MYO3B MGD MGI:2448580
Rattus norvegicus MYO3B RGD RGD:1560313
Canis familiaris MYO3B VGNC VGNC:49692
Felis catus MYO3B VGNC VGNC:63689
Bos taurus MYO3B VGNC VGNC:31825
Others MYO3B NCBI