AEBP1 - AE binding protein 1 Gene

Also Known as ACLP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 165

About AEBP1

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,104,345-44,114,560 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in gall bladder (RPKM 100.0), endometrium (RPKM 86.2) and 23 other tissues.

Summary

This gene encodes a member of Carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

AEBP1 Products (1)

mRNA Protein Name
NM_001129.5 NP_001120.3 adipocyte enhancer-binding protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15654748 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15654748 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15654748 GOA
enables collagen binding IDA
IDA: Inferred from direct assay
29606302 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15654748 GOA
involved in regulation of collagen fibril organization IDA
IDA: Inferred from direct assay
29606302 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AEBP1 Protein Structure

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (399 - 537)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (570 - 895)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (908 - 970)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1158 a.a.
Protein Preferred Names Protein Names

adipocyte enhancer-binding protein 1

  • aortic carboxypeptidase-like protein

関連疾患

Diseases Alias
Ehlers-Danlos Syndrome, Classic-Like, 2

  • EDSCLL2

  • Ehlers-Danlos Syndrome Classic-Like 2

  • Classical-Like Ehlers-Danlos Syndrome Type 2

  • Aebp1-Related Eds

  • Aebp1-Related Ehlers-Danlos Syndrome

  • Classical-Like Eds Type 2

  • Cleds Type 2
Ehlers-Danlos Syndrome, Classic Type, 1

  • Ehlers-Danlos Syndrome, Type I

  • EDSCL1

  • Ehlers-Danlos Syndrome Classic Type 1

  • Ehlers-Danlos Syndrome Type 1

  • Ehlers-Danlos Syndrome, Type I, Formerly

  • Eds1, Formerly

  • Ehlers-Danlos Syndrome, Severe Classic Type, Formerly

  • Eds I, Formerly

  • Ehlers-Danlos Syndrome, Gravis Type, Formerly

  • Ehlers-Danlos Syndrome, Type 1

  • Type I Ehlers-Danlos Syndrome

  • Eds1

  • Eds I

  • Ehlers-Danlos Syndrome, Gravis Type

  • Ehlers-Danlos Syndrome, Severe Classic Type

  • Ehlers-Danlos Syndrome 1

  • Ehlers-Danlos, Classic Syndrome, Type 1

  • Ehlers-Danlos Syndrome Type 2
Gastroschisis

  • Laparoschisis

  • Congenital Fissure Of The Abdominal Cavity

  • Abdominal Wall Defect

  • Abdominal Hernia

  • Hernia, Abdominal

  • Omphalocele

  • Abnormality Of The Abdominal Wall

  • Congenital Omphalocele

  • Coeloschisis

  • Coelioschisis

  • Celoschisis

  • Congenital Para-Umbilical Hernia
Ehlers-Danlos Syndrome, Classic-Like

  • Ehlers-Danlos Syndrome Due To Tenascin-X Deficiency

  • Tnx Deficiency

  • Eds Due To Tnx Deficiency

  • EDSCLL

  • Classical-Like Eds Type 1

  • Classical-Like Ehlers-Danlos Syndrome Type 1

  • Cleds Type 1

  • Ehlers-Danlos Syndrome, Classic-Like, 1

  • Ehlers-Danlos Syndrome Classic-Like 1

  • Classical-Like Ehlers-Danlos Syndrome

  • Classical-Like Eds

  • Eds, Classic-Like Type

  • Ehlers-Danlos Syndrome, Classic-Like Type

  • Cleds

  • Ehlers-Danlos Syndrome, Autosomal Recessive, Due To Tenascin X Deficiency

  • Ehlers-Danlos Syndrome Due To Tenascin X Deficiency

  • Tenascin-X Deficiency

  • Ehlers-Danlos Due To Tenascin X Deficiency

  • Ehlers-Danlos Syndrome Caused By Tenascin-X Deficiency
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Larsen-Like Syndrome B3gat3 Type

  • Larsen-Like Syndrome, B3gat3 Type

  • Multiple Joint Dislocations-Short Stature-Craniofacial Dysmorphism-Congenital Heart Defects Syndrome

  • Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Congenital Heart Defects

  • Joint Dislocations, Multiple, Short Stature, Craniofacial Dysmorphism, Congenital Heart Defects
Caspase 8 Deficiency

  • Autoimmune Lymphoproliferative Syndrome Type 2b

  • Caspase-8 Deficiency

  • Ceds

  • Alps2b

  • Autoimmune Lymphoproliferative Syndrome, Type Iib

  • Alps With Recurrent Viral Infections

  • Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

  • Caspase 8 Deficiency Syndrome

  • Caspase 8 Lymphadenopathy Syndrome

  • Autoimmune Lymphoproliferative Syndrome Type Iib

  • Caspase Eight Deficiency State

  • CASP8D
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-178193A (Rac)-Chem-0199 Inhibitor 99.81% Unkown
HY-178193 Chem-0199 Inhibitor / Unkown
HY-RS00422 AEBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17822 Aebp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24290 Aebp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris AEBP1 VGNC VGNC:37681
Felis catus AEBP1 VGNC VGNC:59662
Macaca mulatta AEBP1 VGNC VGNC:80328
Bos taurus AEBP1 VGNC VGNC:25703
Mus musculus AEBP1 MGD MGI:1197012
Rattus norvegicus AEBP1 RGD RGD:1306922
Others AEBP1 NCBI