EPHX2 - epoxide hydrolase 2 Gene

Also Known as CEH; SEH; ABHD20

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2053

About EPHX2

Cytogenetic location: 8p21.2-p21.1 Genomic coordinates (GRCh38): 8:27,491,143-27,545,564 (from NCBI)

This gene has 12 transcripts (splice variants), 204 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 34.1), small intestine (RPKM 33.0) and 23 other tissues.

Summary

This gene encodes a member of the Epoxide Hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial Hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

EPHX2 Products (4)

mRNA	Protein	Name
NM_001256482.2	NP_001243411.1	bifunctional epoxide hydrolase 2 isoform 2
NM_001256483.2	NP_001243412.1	bifunctional epoxide hydrolase 2 isoform 3
NM_001256484.2	NP_001243413.1	bifunctional epoxide hydrolase 2 isoform 2
NM_001979.6	NP_001970.2	bifunctional epoxide hydrolase 2 isoform1

EPHX2 Protein Structure

HAD_2

Abhydrolase_1

0
100
200
300
400
500
555 a.a.

Protein Preferred Names	Protein Names
bifunctional epoxide hydrolase 2	epoxide hydratase

Recombinant EPHX2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P75227	EPHX2 Protein, Human (sf9, His)	P34913-1/NP_001970.2 (M1-M555)	≥ 90%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Fetal Hydantoin Syndrome	Dilantin Embryopathy Phenytoin Embryopathy Fetal Dihydantoin Syndrome Phenytoin Embryofetopathy Dysmorphism Due To Hydantoin
Staphyloenterotoxemia	Staphylococcal Food Poisoning Staphylococcal Toxaemia Due To Food Staphyloenterotoxicosis
Commensal Bacterial Infectious Disease
Ritter'S Disease	Staphylococcal Scalded Skin Syndrome Pemphigus Neonatorum Ritter Disease Dermatitis Exfoliativa Neonatorum Scalded Skin Syndrome Toxic Epidermal Necrolysis, Subcorneal Type Generalized Exfoliative Disease Ssss Ssss - [Staphylococcal Scalded Skin Syndrome]
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Pyomyositis	Tropical Pyomyositis Myositis Tropicans Myositis Purulenta Tropica Pm Suppurative Myositis Purulent Myositis
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Scarlet Fever	Scarlatina Scarlatina Nos
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-159157	Anti-inflammatory agent 92	Inhibitor	/	Unkown
HY-187425	PROTAC sEH degrader-5	Degrader	/	Unkown
HY-RS04439	EPHX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18273	Ephx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24751	Ephx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	EPHX2	VGNC	VGNC:78487
Canis familiaris	EPHX2	VGNC	VGNC:40416
Macaca mulatta	EPHX2	VGNC	VGNC:81392
Bos taurus	EPHX2	VGNC	VGNC:28542
Mus musculus	EPHX2	MGD	MGI:99500
Rattus norvegicus	EPHX2	RGD	RGD:620732
Others	EPHX2	NCBI