SWAP70 - switching B cell complex subunit SWAP70 Gene

Also Known as HSPC321; SWAP-70

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23075

About SWAP70

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,664,077-9,752,993 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 33.7), spleen (RPKM 30.6) and 24 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SWAP70 Products (2)

mRNA	Protein	Name
NM_001297714.2	NP_001284643.1	switch-associated protein 70 isoform 2
NM_015055.4	NP_055870.2	switch-associated protein 70 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30123108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SWAP70 Protein Structure

PH

0
100
200
300
400
500
585 a.a.

Protein Preferred Names	Protein Names
switch-associated protein 70	SWAP switching B-cell complex 70kDa subunit

SWAP70 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SWAP70	Q9UH65	ZBTB5	Homo sapiens	O15062	Y2H Prey Pooling	25416956
Intra	SWAP70	Q9UH65	ZBTB5	Homo sapiens	O15062	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

SWAP70 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81328	Switch Associated Protein 70 Antibody (YA1073)	WB, IP	Human, Mouse, Rat, Monkey
HY-P81328A	Switch Associated Protein 70 Antibody (YA1073)(PBS only)	WB, IP	Human, Mouse, Rat, Monkey
HY-P85565	Switch Associated Protein 70 Antibody (YA5257)	WB, IP	Human, Mouse, Rat, Monkey

関連疾患

Diseases	Alias
Aleutian Mink Disease	Aleutian Disease
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14063	SWAP70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	SWAP70	VGNC	VGNC:78142
Felis catus	SWAP70	VGNC	VGNC:65867
Bos taurus	SWAP70	VGNC	VGNC:54893
Canis familiaris	SWAP70	VGNC	VGNC:47009
Rattus norvegicus	SWAP70	RGD	RGD:1305579
Mus musculus	SWAP70	MGD	MGI:1298390
Others	SWAP70	NCBI